N-Heterocyclic Carbene-Catalyzed Generation of Homoenolates: Efficient Asymmetric Synthesis of Dispirocyclopentanones by Direct Annulation of Enals and Isoindigos

Catalysts 2026 Open access

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Authors: Zhiwei Jiang, Martial Toffano, Régis Guillot, Chloée Bournaud, Giang Vo‐Thanh
DOI: 10.3390/catal16020138
Cited by: 0
References: 50

Abstract

A highly efficient asymmetric (3+2) annulation between enals and isoindigos was achieved via the N-heterocyclic carbene-catalyzed addition of homoenolates to activated tetrasubstituted C=C double bonds. The protocol provided straightforward access to enantiomerically enriched dispirocyclopentanone bisoxindoles (up to 97% ee) with three contiguous stereocenters, two of which are highly congested vicinal all-carbon quaternary centers.

Fields of Study & Subjects

N-Heterocyclic Carbenes in Organic and Inorganic Chemistry Asymmetric Synthesis and Catalysis Synthesis of Indole Derivatives

Publication details

Journal / source
Catalysts
Volume
16
Issue
2
Pages
138–138
Publication date
2 February 2026
Language
EN