Senescence as a Driver of Smooth Muscle Cell Plasticity and Atherosclerosis: Mechanisms and Therapeutic Opportunities
Abstract
Cell senescence is increasingly recognized as a key driver of atherosclerosis progression. Senescent smooth muscle cells (SMCs) lose their proliferative capacity and adopt a pro-inflammatory profile, contributing to impaired vessel repair and weakening of the fibrous cap. Moreover, senescence promotes SMC dedifferentiation and phenotypic modulation into unfavorable phenotypes associated with plaque destabilization. In this review, we will discuss how cell senescence is induced in atherosclerotic plaques, how this influences SMC plasticity, and how this impacts plaque stability. We will also evaluate the potential of current and experimental anti-atherosclerotic drugs to target SMC senescence and/or SMC phenotypic modulation.
Fields of Study & Subjects
Telomeres
Telomerase
and Senescence
Skin Protection and Aging
Neutrophil
Myeloperoxidase and Oxidative Mechanisms
Publication details
- Journal / source
- Cells
- Publisher
- MDPI AG
- Volume
- 15
- Issue
- 2
- Pages
- 114–114
- Publication date
- 8 January 2026
- Language
- EN