Peroxisome Proliferator-Activated Receptor β/δ: A Link Between Metabolism, Inflammation, and Fibrosis in Metabolic Dysfunction-Associated Steatotic Liver Disease

Cells 2026 Open access

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Authors: Xavier Palomer, Jue-Rui Wang, Xiaoman Tang, Siyuan Wu, Ricardo Rodríguez‐Calvo, Walter Wahli, Manuel Vázquez-Carrera
DOI: 10.3390/cells15050464
Cited by: 4
References: 96

Abstract

Metabolic dysfunction-associated steatotic liver disease (MASLD) is considered a hepatic manifestation of insulin resistance and ranges from isolated steatosis to metabolic dysfunction-associated steatohepatitis (MASH). Hepatocyte ballooning, indicative of hepato-cellular damage, and liver inflammation, with or without fibrosis, are characteristic of MASH. Evidence shows that peroxisome proliferator-activated receptor β/δ (PPARβ/δ), expressed in the major liver cells (hepatocytes, Kupffer cells, cholangiocytes, and hepatic stellate cells), may help prevent the progression of MASLD by ameliorating insulin resistance, lipotoxicity, inflammation, and fibrosis. In this review, we summarize the molecular mechanisms by which PPARβ/δ attenuates the progression of MASLD and discuss future research perspectives.

Fields of Study & Subjects

Liver Disease Diagnosis and Treatment Peroxisome Proliferator-Activated Receptors Drug-Induced Hepatotoxicity and Protection

Publication details

Journal / source
Cells
Publisher
MDPI AG
Volume
15
Issue
5
Pages
464–464
Publication date
5 March 2026
Language
EN