The Multifaceted Role of microRNA-10b (miR-10b) in Glioblastoma: From Oncogenic Driver to Therapeutic Target
Abstract
Glioblastoma (GBM) remains one of the most lethal and treatment-resistant human malignancies, characterized by extreme molecular heterogeneity and a highly immunosuppressive tumor microenvironment (TME). MicroRNAs are a set of small endogenous non-coding RNA molecules which play critical roles in various biological processes including carcinogenesis. Recent evidence identifies microRNA-10b (miR-10b) as a regulator of gliomagenesis, with glioblastoma exhibiting a unique state of "oncogene addiction" to this molecule. This review summarizes current research on the mechanistic roles of miR-10b in GBM tumor progression and immune evasion, evaluates innovative antisense oligonucleotide delivery systems, and explores the clinical potential of combining miR-10b inhibition with standard-of-care treatments.
Fields of Study & Subjects
MicroRNA in disease regulation
Circular RNAs in diseases
Cancer-related molecular mechanisms research
Publication details
- Journal / source
- Cells
- Publisher
- MDPI AG
- Volume
- 15
- Issue
- 9
- Pages
- 784–784
- Publication date
- 26 April 2026
- Language
- EN