Obesity-Related Changes in Growth Hormone Stimulation Test Performance Under Pediatric Growth Hormone Deficiency
Abstract
Background/Objectives: The objective of this study is to determine the extent to which obesity alters the diagnostic reliability of the clonidine stimulation test (CST) for growth hormone deficiency (GHD) and whether incorporating insulin-like growth factor 1 (IGF-1) and the annual growth velocity standard deviation score (GV SDS) improves diagnostic precision. Methods: This retrospective study included 101 children evaluated for short stature using the clonidine stimulation test, with serum GH concentrations determined by a two-site, solid-phase, enzyme-labeled chemiluminescent immunometric assay (Immulite 2000 XPi, Siemens Healthcare Diagnostics, USA). Diagnostic performance was compared between overweight/obese (n = 47) and normal-weight (n = 54) groups. A two-step algorithm was evaluated: Step 1 applied a GH peak threshold of
Fields of Study & Subjects
Growth Hormone and Insulin-like Growth Factors
Pituitary Gland Disorders and Treatments
Adrenal Hormones and Disorders
Publication details
- Journal / source
- Children
- Publisher
- MDPI AG
- Volume
- 13
- Issue
- 2
- Pages
- 299–299
- Publication date
- 21 February 2026
- Language
- EN