Is Pulse Co-Oximetry a Reliable Alternative to Invasive Hemoglobin Measurement in Pediatric Neurosurgical Procedures?

Background/Objectives: Pediatric neurosurgical procedures often involve significant blood loss and rapid hemodynamic shifts, necessitating accurate hemoglobin (Hb) monitoring. While continuous non-invasive Hb (SpHb) monitoring offers real-time trending, its accuracy in high-risk pediatric populations remains debated. We aimed to evaluate the diagnostic accuracy and clinical utility of SpHb compared to invasive arterial blood gas (ABG) analysis in pediatric patients undergoing cranial and spinal surgeries. Methods: This prospective, observational study enrolled 60 pediatric patients (aged 0–16 years) scheduled for high-risk neurosurgery. SpHb was measured continuously and compared with intermittent ABG-Hb values. Statistical analysis included Bland–Altman agreement, Pearson’s correlation, and Error Grid Analysis. Subgroup analyses assessed the impact of the Perfusion Index (PI), hypotension, and metabolic acidosis on device performance. Results: Data from 57 patients (median age: 12 months, interquartile range: 6–42 months; 70.2% aged