Intraoperative Low-Dose Methadone for Pediatric Posterior Spinal Fusion: A Single-Center Retrospective Cohort Study

Children 2026 Open access

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Authors: Roshni Cheema, Kristina L. Boyd, Mihaela Visoiu, Hsing‐Hua Sylvia Lin, Scott E. Licata, Ruth Ressler, Vishali Veeramreddy, Shraddha Sriram, Selena Rashid, Senthilkumar Sadhasivam, Paul Hoffmann
DOI: 10.3390/children13030400
Cited by: 0
References: 31

Abstract

Background: Posterior spinal fusion (PSF) for adolescent idiopathic scoliosis causes significant postoperative pain and high opioid requirements. Methadone, with dual μ- and κ-opioid agonism and NMDA antagonism, provides long-acting analgesia and may reduce perioperative opioid use. This study evaluated whether perioperative low-dose methadone (0.1 mg/kg) improves postoperative pain and opioid outcomes after pediatric PSF. Methods: In this single-center retrospective cohort study (January 2019–June 2023), pediatric patients

Fields of Study & Subjects

Anesthesia and Pain Management Scoliosis diagnosis and treatment Pain Management and Opioid Use

Publication details

Journal / source
Children
Volume
13
Issue
3
Pages
400–400
Publication date
13 March 2026
Language
EN