Cancer During Pregnancy: Navigating Clinical and Research Challenges

Current Oncology 2026 Open access

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Authors: Mackenzie K. Callaway, Lizelle Comfort, Dhivyaa Anandan, Ruby Sharma, Narjust Florez, Traci R. Lyons, Doris Germain, Kathleen R. Cho, Burton L. Rochelson, Clarissa Bonanno, Kutluk Oktay, Sudarshana Roychoudhury
+11 more Eileen O’donnell, Richard Barakat, Joanne Marquardt, Diana W. Bianchi, Elyce Cardonick, Larry Norton, Ann H. Partridge, Susan M. Domchek, Virginia F. Borges, Frédéric Amant, Camila O. Dos Santos
DOI: 10.3390/curroncol33050296
Cited by: 1
References: 90

Abstract

The incidence of cancer during pregnancy is rising, yet scientific understanding and clinical management remain underdeveloped. Delayed diagnoses, limited therapeutic options, and lack of safety data exacerbate the clinical challenges of treating cancer during pregnancy. Further, the biology of gestational cancers is poorly understood due to the scarcity of model systems and mechanistic studies. This manuscript presents a multidisciplinary perspective from a group of researchers and clinicians to evaluate the current state of pregnancy-associated cancers, identify unmet clinical and biological questions, and propose strategies to improve diagnosis, treatment, and maternal-fetal outcomes.

Fields of Study & Subjects

Cancer Risks and Factors Birth Development and Health Reproductive Biology and Fertility

Publication details

Journal / source
Current Oncology
Publisher
MDPI AG
Volume
33
Issue
5
Pages
296–296
Publication date
19 May 2026
Language
EN