Integrating Large Language Models with Deep Learning for Breast Cancer Treatment Decision Support

Background/Objectives: Breast cancer is one of the most common malignancies, but its heterogeneous molecular subtypes make treatment decision-making complex and patient-specific. Both the pathology reports and the electronic medical record (EMR) play a critical role for an appropriate treatment decision. This study aimed to develop an integrated clinical decision support system (CDSS) that combines a large language model (LLM)-based pathology analysis with deep learning-based treatment prediction to support standardized and reliable decision-making. Methods: Real-world data (RWD) obtained from a cohort of 5015 patients diagnosed with breast cancer were analyzed. Meta-Llama-3-8B-Instruct automatically extracted the TNM stage and tumor size from the pathology reports, which were then integrated with EMR variables. A multi-label classification of 16 treatment combinations was performed using six models, including Decision Tree, Random Forest, GBM, XGBoost, DNN, and Transformer. Performance was evaluated using accuracy, macro/micro-averaged precision, recall, F1 score, and AUC. Results: Using combined LLM-extracted pathology and EMR features, GBM and XGBoost achieved the highest and most stable predictive performance across all feature subset configurations (macro-F1 ≈ 0.88–0.89; AUC = 0.867–0.868). Both models demonstrated strong discrimination ability and consistent recall and precision, highlighting their robustness for multi-label classification in real-world settings. Decision Tree and Random Forest showed moderate but reliable performance (macro-F1 = 0.84–0.86; AUC = 0.849–0.821), indicating their applicability despite lower predictive capability. By contrast, the DNN and Transformer models produced comparatively lower scores (macro-F1 = 0.74–0.82; AUC = 0.780–0.757), especially when using the full feature set, suggesting limited suitability for structured clinical data without strong contextual dependencies. These findings indicate that gradient-boosting ensemble approaches are better optimized for tabular medical data and generate more clinically reliable treatment recommendations. Conclusions: The proposed artificial intelligence-based CDSS improves accuracy and consistency in breast cancer treatment decision support by integrating automated pathology interpretation with deep learning, demonstrating its potential utility in real-world cancer care.