Association of Intraoperative Parathyroid Hormone Decline with Early Postoperative Hypocalcemia: A Single-Center Retrospective Study

Diagnostics 2026 Open access

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Authors: Suat Evirgen, Elif Menekse, Ecem Avci, Burak Yasin Avcı, Çiğdem Tura Bahadır, Cafer Polat
DOI: 10.3390/diagnostics16040636
Cited by: 1
References: 24

Abstract

Background/Objectives: Postoperative early hypocalcemia (PEH) is a key postoperative issue after parathyroidectomy in primary hyperparathyroidism. It often leads to long-lasting hypocalcemia, requiring more calcium and active vitamin D supplements. This study aimed to determine whether the extent of intraoperative parathyroid hormone (PTH) decline, measured 15 min after parathyroid tumor excision, could serve as a reliable intraoperative rule-out marker for PEH. Methods: We conducted a retrospective review of 88 adult patients who underwent surgical intervention for a solitary parathyroid tumor at a single institution. Postoperative early hypocalcemia (PEH) was defined as a total serum calcium level

Fields of Study & Subjects

Parathyroid Disorders and Treatments Thyroid and Parathyroid Surgery Vitamin D Research Studies

Publication details

Journal / source
Diagnostics
Publisher
MDPI AG
Volume
16
Issue
4
Pages
636–636
Publication date
22 February 2026
Language
EN