Sexual Dimorphism and Age-Related Structural Changes in the Human Larynx: A Morphometric Study with Histological Correlates Relevant to Voice and Diagnostic Assessment

Diagnostics 2026 Open access

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Authors: Alina Elisabeta Anglitoiu, Ahmed Abu-Awwad, Bogdan Anglitoiu, Daniela Gurgus, Daniel Pop, Anca M. Bînă, Zoran Laurentiu Popa, Mihai Sandesc, Simona-Alina Abu-Awwad
DOI: 10.3390/diagnostics16050725
Cited by: 2
References: 46

Abstract

Background/Objectives: The human larynx exhibits marked sexual dimorphism and undergoes age-related structural remodeling, both of which influence voice characteristics and have important implications for diagnostic assessment. While sex-related differences in laryngeal size are well recognized, the extent to which aging contributes to dimensional versus qualitative structural changes remains incompletely defined. This study aimed to analyze sex- and age-related morphometric and histological characteristics of the human larynx, with a focus on features relevant to voice evaluation and diagnostic interpretation. Methods: A cross-sectional anatomical study was conducted on 80 cadaveric human larynges preserved in 10% buffered formalin. Specimens were stratified by sex and age (

Fields of Study & Subjects

Voice and Speech Disorders Thyroid and Parathyroid Surgery Dysphagia Assessment and Management

Publication details

Journal / source
Diagnostics
Publisher
MDPI AG
Volume
16
Issue
5
Pages
725–725
Publication date
28 February 2026
Language
EN