A Confidence-Gated Hybrid CNN Ensemble for Accurate Detection of Parkinson’s Disease Using Speech Analysis

Parkinson’s Disease (PD) is a progressive neurodegenerative disorder for which early and reliable diagnosis remains challenging. To address this challenge, the key innovation of this work is a confidence-gated fusion mechanism that dynamically weights classifier outputs based on per-sample prediction certainty, overcoming the limitations of static ensemble strategies. Building on this idea, we propose a Confidence-Gated Hybrid CNN Ensemble that integrates CNN-based acoustic feature extraction with heterogeneous classifiers, including XGBoost, Support Vector Machines, and Random Forest. By adaptively modulating the contribution of each classifier at the sample level, the proposed framework enhances robustness against data imbalance, inter-speaker variability, and feature complexity. The method is evaluated on two benchmark PD speech datasets, where it consistently outperforms conventional machine learning and ensemble approaches, achieving a best classification accuracy of up to 97.9% while maintaining computational efficiency compatible with real-time deployment. These results highlight the effectiveness and clinical potential of confidence-aware ensemble learning for non-invasive PD detection.