ARS2, a Cofactor of CBC, Promotes Meiotic Silencing by Unpaired DNA
Abstract
, a surveillance mechanism called meiotic silencing by unpaired DNA (MSUD) is maintained to monitor these selfish elements. MSUD utilizes common RNA interference (RNAi) factors, including the SMS-2 Argonaute, to target mRNAs from genes lacking a pairing partner during meiosis. In eukaryotes, an mRNA transcript is typically bound at the 5' cap by the cap-binding complex (CBC), which assists in its nuclear export. Previously, we discovered that CBC and its interactor NCBP3 mediate MSUD, possibly by guiding the perinuclear SMS-2 to effectively recognize exported mRNAs. Here, we report that ARS2, a CBC cofactor, is involved in MSUD. ARS2 interacts with both CBC and NCBP3, and it may help bring them together. In addition to its role in silencing, ARS2 also contributes to vegetative growth and sexual sporulation.
Fields of Study & Subjects
DNA Repair Mechanisms
Bacterial Genetics and Biotechnology
Fungal and yeast genetics research
Publication details
- Journal / source
- Epigenomes
- Publisher
- MDPI AG
- Volume
- 10
- Issue
- 1
- Pages
- 6–6
- Publication date
- 21 January 2026
- Language
- EN