Fermentation-Driven Generation of α-Glucosidase Inhibitory Whey Peptides by Marine-Derived Probiotic Lacticaseibacillus casei DS31: Activity Enrichment and Peptidomics

Fermentation 2026 Open access

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Authors: Han Zhang, Xu Tang, Longhe Yang, Shen Yang, Peng Wu
DOI: 10.3390/fermentation12020074
Cited by: 0
References: 46

Abstract

This study investigated the generation of α-glucosidase inhibitory peptides from whey protein fermented by the marine-derived probiotic Lacticaseibacillus casei DS31 (isolated from the intestinal microbiota of the large yellow croaker, Larimichthys crocea) and assessed their potential for practical glycemic management. Fermentation markedly increased inhibitory activity, with the freeze-dried crude supernatant exhibiting an IC50 of 2.115 mg/mL. Activity was further enriched through stepwise purification: ultrafiltration (

Fields of Study & Subjects

Protein Hydrolysis and Bioactive Peptides Natural Antidiabetic Agents Studies Probiotics and Fermented Foods

Publication details

Journal / source
Fermentation
Volume
12
Issue
2
Pages
74–74
Publication date
29 January 2026
Language
EN