Investigation of SNPs at NKCC Gene of Scylla paramamosain to Unveil the Low-Salinity Tolerance Phenotype

Fishes 2026 Open access

Read full text
Authors: Chunyan Yin, Yanqing Ma, Zhiqiang Liu, X.Q. Wang, Keyi Ma, Wei Wang, Chunyan Ma, Fengying Zhang
DOI: 10.3390/fishes11010031
Cited by: 0
References: 52

Abstract

The Na+/K+/2Cl− cotransporter (NKCC) gene encodes a critical membrane transporter involved in cellular ion homeostasis and plays a pivotal role in osmoregulation and salinity adaptation in aquatic organisms. This study identified and validated SNP markers in the NKCC gene associated with low-salinity tolerance in Scylla paramamosain. Four SNPs (g.196C>A, g.8374T>A, g.8385T>A and g.91143T>A) were screened and genotyped in low-salinity tolerant and intolerant groups. Association analysis revealed that mutant genotypes at all four sites were significantly enriched in the tolerant group (p

Fields of Study & Subjects

Physiological and biochemical adaptations Neurobiology and Insect Physiology Research Aquatic Ecosystems and Phytoplankton Dynamics

Publication details

Journal / source
Fishes
Volume
11
Issue
1
Pages
31–31
Publication date
5 January 2026
Language
EN