Rectal In Situ Thermosensitive Gel Loaded with Agomelatine-Silver Nanoparticles: Formulation and Characterization

Gels 2026 Open access

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Authors: Marwa Helmy Abdallah, Mohamed S. Mohamed, Tamer M. Shehata, Wael A. Abdelhafez, Mahmoud M. A. Elsayed, H. E. Ramadan, Islam Khalid Kamal, Abdulsalam M. Kassem, Mahmoud Elkot Mostafa, Ayman Salama, Reda A. Mahmoud, Ahmed A. El-Shenawy
DOI: 10.3390/gels12010051
Cited by: 1
References: 66

Abstract

Agomelatine (AG) is a novel antidepressant characterized by distinct mechanism of action and minimal side effects. However, extensive first-pass hepatic metabolism limits its clinical efficacy after oral administration, leading to low bioavailability (

Fields of Study & Subjects

Hydrogels: synthesis properties applications Advanced Drug Delivery Systems Supramolecular Self-Assembly in Materials

Publication details

Journal / source
Gels
Publisher
MDPI AG
Volume
12
Issue
1
Pages
51–51
Publication date
2 January 2026
Language
EN