Bioinformatic Analysis of Differentially Expressed Long Non-Coding RNAs in Skeletal Muscle Following Aerobic and Resistance Exercise

Background/Objectives: Emerging evidence suggests that long non-coding RNA (lncRNA) molecules influence the adaptive response to exercise, but how lncRNA responses differ between endurance and resistance exercise (RE) modalities is poorly understood. The purpose of this study was to bioinformatically infer the expression of lncRNA in skeletal muscle following acute aerobic exercise (AE) and RE. Methods: We downloaded publicly available RNA-seq data, performed a differential expression (DE) analysis, and compared lncRNA expression profiles between different exercise types (AE vs. RE) at three timepoints: baseline, 1 h post-exercise, and 4 h post-exercise. Results: We observed distinct lncRNA profiles between acute AE and RE at different timepoints, suggesting that lncRNA perform distinct roles in controlling the response to different exercise modalities in skeletal muscle. Conclusions: Future studies should investigate the specific roles of these lncRNAs in the response to acute exercise in skeletal muscle.