Age-Stratified Differences in Cardio–Reno–Metabolic Risk Profiles

Background: Susception to cardio–reno–metabolic disorders increases markedly with age; however, the dominant contributors to risk may differ across the adult life course. While metabolic abnormalities often predominate at younger ages, vascular and renal alterations become more prominent in older populations. Understanding how these risk components reconfigure with aging may inform age-tailored prevention strategies. Methods: This cross-sectional observational study included 287 adults undergoing clinical and biochemical evaluation for cardio–metabolic risk. Participants were stratified into three age categories: 75 years (n = 28). Anthropometric measurements, blood pressure, metabolic parameters, liver enzymes, inflammatory markers, and renal function indices were assessed. Insulin resistance was estimated using the triglyceride–glucose (TyG) index, and renal function was evaluated by estimated glomerular filtration rate (eGFR) and urinary albumin-to-creatinine ratio (UACR). Comparisons across age groups were performed using one-way analysis of variance (ANOVA). Results: Younger participants (