Determinants of Chemotherapy Convenience and Satisfaction: The Role of Symptom and Psychological Burden in Cancer Patients—A Cross-Sectional Study

Background: Chemotherapy-related symptom burden and psychological distress may significantly influence patients’ perceptions of treatment convenience and satisfaction, yet evidence in the Greek oncology population remains limited. Methods: A cross-sectional study was conducted among 150 cancer patients receiving chemotherapy in a tertiary hospital. Data were collected using CCSQ, ESAS-r, PHQ-2, GAD-2, and WHO-5. Pearson correlations and multiple linear regression analyses were performed. Results: Higher levels of depressive symptoms and anxiety were significantly associated with lower chemotherapy convenience and satisfaction (e.g., PHQ-2: r = −0.659 to −0.584, p < 0.001; GAD-2: r = −0.623 to −0.469, p < 0.001). Depressed mood emerged as a significant negative predictor of convenience (β = −0.39, p = 0.015) and concerns (β = −0.39, p = 0.005), while anxiety independently predicted satisfaction (β = 0.45, p = 0.007). Conclusions: Chemotherapy experience is strongly associated with psychological and symptom burden. These findings highlight the importance of integrating psychosocial assessment into routine oncology care.