Beyond the Take-Home Pathway: Community-Level Pesticide Exposure Among Children Living in an Intensively Cultivated Agricultural Landscape

Children living in agricultural regions are exposed to pesticides through multiple environmental and occupational exposure processes; however, the relative contribution of these processes remains insufficiently characterised in many rural contexts of the Global South. This study assessed pesticide exposure among children residing in an agricultural community in western Mexico characterised by close spatial proximity between residential areas and intensively cultivated fields. Urine samples were collected from children at two points in the agricultural cycle (March and December 2018). Pesticide concentrations were determined using liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS). Paired longitudinal analyses were conducted to evaluate intra-individual changes in detection frequencies and urinary concentrations across sampling periods. Multiple pesticides were detected, including compounds with near-universal presence across both sampling periods. Significant increases in urinary concentrations were observed between March and December for several pesticides, consistent with seasonal agricultural dynamics, while no systematic differences were identified between children from agricultural and non-agricultural households. These findings indicate that pesticide exposure in this setting operates as a community-level exposure regime that is both structurally produced and territorially embedded. Exposure patterns reflect the convergence of agricultural practices, environmental dispersion processes, and spatial configurations that extend beyond occupational boundaries. The results highlight the limitations of risk models focused exclusively on individual or occupational exposure and underscore the need for public health strategies that address pesticide exposure as a structurally produced and territorially embedded condition.