iPSC-Derived Endothelial Cells as Experimental Models for Predictive and Personalized Strategies in Cardiovascular and Cerebrovascular Disease
Abstract
Endothelial cells (ECs) regulate vascular homeostasis, and their dysfunction is a key driver of many cardiovascular and cerebrovascular diseases. Human-induced pluripotent stem cell-derived endothelial cells (hiPSC-ECs) provide access to patient-specific vascular cells that can be directed toward arterial, venous, or organotypic phenotypes, enabling personalized in vitro modeling of endothelial pathology. In this review, we discuss how patient-specific iPSC-ECs are used as predictive and personalized two- and three-dimensional models to dissect disease mechanisms and prioritize targeted therapies. We highlight some limitations of this methodology and outline future directions for integrating iPSC-EC-based assays into individualized treatment algorithms.
Fields of Study & Subjects
Angiogenesis and VEGF in Cancer
3D Printing in Biomedical Research
Pluripotent Stem Cells Research
Publication details
- Journal / source
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Volume
- 27
- Issue
- 2
- Pages
- 780–780
- Publication date
- 13 January 2026
- Language
- EN