N, N-Dimethyl-4-Aminopyridine- and Aluminum Isopropoxide-Catalysed Ring-Opening Polymerizations of β-Butyrolactone for the Antimicrobial Oligohydroxybutyrate

International Journal of Molecular Sciences 2026 Open access

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Authors: Qi Bao, Pui‐Kin So, Siu Lun Leung, Polly H. M. Leung, XM Tao
DOI: 10.3390/ijms27020999
Cited by: 0
References: 55

Abstract

Infectious pathogens pose serious threats to public health, necessitating the development of more antimicrobials. In this study, oligohydroxybutyrates were obtained through the catalyzed polymerization of β-butyrolactone using N, N-dimethyl-4-aminopyridine (DMAP) and aluminum isopropoxide [Al(OiPr)3] and applied as sustainable antimicrobial agents. The poly3-hydroxybutyrate (PHB) oligomers exhibited broad-spectrum antibacterial activities against both Gram-negative (E. coli) and Gram-positive (S. aureus) model bacteria. Additionally, PHB oligomers displayed robust (inhibiting rate: >95%) and rapid (action time:

Fields of Study & Subjects

biodegradable polymer synthesis and properties Antimicrobial agents and applications Polymer Synthesis and Characterization

Publication details

Journal / source
International Journal of Molecular Sciences
Volume
27
Issue
2
Pages
999–999
Publication date
19 January 2026
Language
EN