High-Throughput Sequencing Decodes tsRNA Landscapes: Insights into Cancer Biomarkers and Therapeutic Targets
Abstract
Transfer RNA-derived small RNAs (tsRNAs) represent an emerging category of small non-coding RNAs generated through specific cleavage of precursor or mature tRNAs. Increasingly recognized as pivotal players in the pathogenesis of complex malignancies, tsRNAs not only regulate cancer progression but also hold promising clinical potential for cancer diagnosis and treatment. This review highlights recent advances in the application of high-throughput sequencing technologies in the systematic identification of tsRNAs, with a focus on their roles in cancer diagnosis, prognostic assessment, and targeted therapy. Delving into the translational medicine dimensions of tsRNAs may provide novel strategies for molecular diagnosis and therapeutic interventions in oncology.
Fields of Study & Subjects
RNA modifications and cancer
Cancer-related molecular mechanisms research
MicroRNA in disease regulation
Publication details
- Journal / source
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Volume
- 27
- Issue
- 4
- Pages
- 1949–1949
- Publication date
- 18 February 2026
- Language
- EN