Tricyclic Pyrrole-Based Compounds as Zika Virus Inhibitors

International Journal of Molecular Sciences 2026 Open access

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Authors: Gabriele Murineddu, Erika Plicanti, Paola Corona, Carlo Di Marzo, Battistina Asproni, Ilenia Lupinu, Giulia Lottini, Sandra Piras, Antonio Carta
DOI: 10.3390/ijms27052306
Cited by: 1
References: 22

Abstract

A small library of 23 pyrrole-based tricyclic derivatives bearing bulky amine moieties was synthesized, and all were evaluated for their antiviral activities against ZIKV and SARS-CoV. Three compounds, derivatives 2g, 2h and 2j, elicited interesting activity against ZIKV: compound 2g, containing a bornylamine residue, showed the best activity against Huh-7 cells with EC50 and CC50 values of 0.4 μM and 230.5 μM, respectively, and a Selectivity Index (SI) of 501. All three compounds reduce ZIKV yield primarily by impairing viral protein.

Fields of Study & Subjects

Mosquito-borne diseases and control Diverse Scientific Research Studies Respiratory viral infections research

Publication details

Journal / source
International Journal of Molecular Sciences
Publisher
MDPI AG
Volume
27
Issue
5
Pages
2306–2306
Publication date
28 February 2026
Language
EN