The Art of Domesticating Proteins: How Cancer Cells Adapt to Therapeutic and Environmental Stressors
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Cellular survival and adaptability depend on the dynamic regulation of proteins-the central actors of biological systems. Through mechanisms such as post-translational modifications, protein turnover, and the formation of membraneless organelles, cells can sense and respond to a variety of stressors. Recent advances in artificial intelligence and chemical biology have provided powerful tools to study and manipulate these processes, paving the way for novel therapeutic strategies in cancer. This review explores how cells "tame" their proteome in response to stress by coordinating protein synthesis, modification, degradation, and structural organization to maintain functional resilience.
Fields of Study & Subjects
Ubiquitin and proteasome pathways
Heat shock proteins research
Advanced Proteomics Techniques and Applications
Publication details
- Journal / source
- International Journal of Molecular Sciences
- Volume
- 27
- Issue
- 6
- Pages
- 2662–2662
- Publication date
- 14 March 2026
- Language
- EN