Functional and Histological Analysis of Stem Cell and Amniotic Membrane Implantation After Acute Myocardial Infarction with Left Ventricular Dysfunction: Experimental Study

International Journal of Molecular Sciences 2026 Open access

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Authors: Isabella Cristina Mendes Rossa, Marcos Denk, Luize Kremer Gamba, Anna Clara Faidiga Silva, Julia Letícia de Bortolo, Igor Ramos Lima, Paulo Cesar Lock Silveira, Eltyeb Abdelwahid, Márcia Olandoski, Luiz César Guarita-Souza, Lucia de Noronha, Júlio César Francisco
+1 more Luiz César Guarita-Souza
DOI: 10.3390/ijms27083397
Cited by: 0
References: 22

Abstract

Acute myocardial infarction (AMI) results from a lack of oxygen supply to the myocardium, leading to the loss of cardiomyocytes and their replacement with fibrotic scar tissue. This process is closely associated with the development of heart failure. Regenerative medicine has emerged as a promising strategy to enhance treatment outcomes in severe cases of heart failure. This study aimed to evaluate myocardial regeneration after AMI using a biomaterial composed of mononuclear stem cells and human amniotic membrane. A total of 120 Wistar rats were subjected to experimentally induced AMI. On the 7th day post-infarction, rats with an ejection fraction of

Fields of Study & Subjects

Tissue Engineering and Regenerative Medicine Cardiac Fibrosis and Remodeling Cardiac Structural Anomalies and Repair

Publication details

Journal / source
International Journal of Molecular Sciences
Volume
27
Issue
8
Pages
3397–3397
Publication date
10 April 2026
Language
EN