Sepsis in the Emergency Department: Different Faces, Same Fate? A Sex-Based Prognostic Analysis
Abstract
We aimed to evaluate the clinical characteristics of male and female patients with sepsis and to investigate their potential sex-specific differences in the prognostic weight. Retrospective analysis, including all patients with sepsis admitted to the Emergency Department High-Dependency Unit, between June 2008 and October 2025. Clinical data were collected using a standardized template. The endpoints were day-7 and day-28 mortality rates. The study population included 1527 patients, with a mean age of 74 ± 13 years, and female sex comprising 44%. Women were older (77 ± 13 vs. 73 ± 13 yrs, p ≤ 0.001), with a lower prevalence of cancer (19% vs. 27%, p = 0.009) than men. Conversely, a pulmonary (34% vs. 66%) or abdominal (40% vs. 60%) sepsis source was more frequent in men (both
Fields of Study & Subjects
Sepsis Diagnosis and Treatment
Immune Response and Inflammation
Emergency and Acute Care Studies
Publication details
- Journal / source
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Volume
- 27
- Issue
- 9
- Pages
- 3753–3753
- Publication date
- 23 April 2026
- Language
- EN