Mitochondrial Regulation of the NLRP3 Inflammasome in Diabetic Kidney Disease: From Mechanisms to Therapeutic Strategies
Abstract
Despite current therapies, persistent chronic inflammation remains an important contributor to residual renal risk in diabetic kidney disease (DKD). The NLRP3 inflammasome is a key driver of this inflammatory cascade, with mitochondria serving as a central hub that translates metabolic stress into NLRP3 activation via mitochondrial reactive oxygen species (mtROS) and oxidized mitochondrial DNA (ox-mtDNA). This review delineates the signaling network of the mitochondria-NLRP3 inflammasome axis in DKD and evaluates its potential as a therapeutic target to improve patient outcomes.
Fields of Study & Subjects
Inflammasome and immune disorders
Dialysis and Renal Disease Management
Acute Kidney Injury Research
Publication details
- Journal / source
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Volume
- 27
- Issue
- 11
- Pages
- 4819–4819
- Publication date
- 27 May 2026
- Language
- EN