Cytokine-Family Biomarker Candidates for Small Abdominal Aortic Aneurysm Identified via Integrated mRNA and Protein Expression Profiling

International Journal of Molecular Sciences 2026 Open access

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Authors: Piotr Stabiszewski, Daniel Zalewski, Przemysław Kołodziej, Marta Ziaja‐Sołtys, Joanna Łuszczak, Magdalena Szymańska, Alicja Petniak, Jacek Bogucki, Piotr Terlecki, Barbara Stawarz, Janusz Kocki, Marcin Feldo
+1 more Anna Bogucka‐Kocka
DOI: 10.3390/ijms27114863
Cited by: 1
References: 97

Abstract

Abdominal aortic aneurysm (AAA) is a chronic vascular disease characterized by localized dilatation of the abdominal aorta. This condition is frequently underdiagnosed and carries a high mortality rate (65–85%) due to aneurysm rupture. Although numerous candidate biomarkers have been identified for AAA, none have been successfully implemented in clinical diagnostic procedures for AAA screening. This highlights the critical need for the discovery and validation of reliable biomarkers to improve early detection and risk stratification in AAA. Therefore, in our study, we aimed to identify small AAA (sAAA) biomarker candidates among the key cytokines and receptors of IL-1, IL-6, IL-8, IL-10, and IL-17 families on gene expression and plasma protein levels. Comparative analysis was conducted between a group of 100 men with sAAA (

Fields of Study & Subjects

Aortic aneurysm repair treatments Connective tissue disorders research Aortic Disease and Treatment Approaches

Publication details

Journal / source
International Journal of Molecular Sciences
Publisher
MDPI AG
Volume
27
Issue
11
Pages
4863–4863
Publication date
28 May 2026
Language
EN