Elevated Estradiol and DHT Levels in the Prostatic Stroma as Key Drivers of Benign Prostatic Hyperplasia Pathogenesis

International Journal of Molecular Sciences 2026 Open access

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Authors: Tomislav Pejčić, Milka B. Jadranin, Sinisa F. Djurasevic, Milica Kalaba, Biljana Dojčinović, Milica Zeković, Uroš Bumbaširević, Darko Jovanovic, Darko Laketić, Živoslav Tešić, Tomislav B. Tosti
DOI: 10.3390/ijms27156785
Cited by: 1
References: 78

Abstract

While dihydrotestosterone (DHT) has traditionally been considered the principal steroid in benign prostatic hyperplasia (BPH) pathogenesis, the role of estradiol (E2) and its relationship with local androgen accumulation remain unclear. This study investigated whether transition zone (TZ) tissue concentrations of E2, testosterone, and DHT are associated with prostate enlargement. TZ tissue cores were collected from 80 men undergoing prostate biopsy. Patients were stratified by total prostate volume (TPV): small (

Fields of Study & Subjects

Urinary Bladder and Prostate Research Prostate Cancer Treatment and Research Hormonal and reproductive studies

Publication details

Journal / source
International Journal of Molecular Sciences
Publisher
MDPI AG
Volume
27
Issue
15
Pages
6785–6785
Publication date
29 July 2026
Language
EN