Rare Variants May Influence Disease Risk and Clinical Features in Sporadic Late-Onset Chinese Parkinson’s Disease Patients

International Journal of Molecular Sciences 2026 Open access

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Authors: Ryan Wui Hang Ho, Zewei Xiong, Regina Cheuk‐Lam Lo, Huifang Liu, Philip Wing‐Lok Ho, Pak-Chung Sham, Shu-Leong Ho, SF Pang
DOI: 10.3390/ijms27177653
Cited by: 0
References: 58

Abstract

BackgroundThe heritability in Parkinson’s disease (PD) may be contributed by rare variants (RVs) in candidate genes. Currently there is limited genetic data on Chinese PD patients.ObjectiveWe aim to identify RVs in Chinese PD patients and investigate their relationships with risk and phenotype of PD.MethodsWe performed targeted exome sequencing of 29 PD genes on 311 late-onset, sporadic Chinese PD patients. Burden of total and individual RVs (minor allele frequency

Fields of Study & Subjects

Parkinson's Disease Mechanisms and Treatments RNA regulation and disease

Publication details

Journal / source
International Journal of Molecular Sciences
Volume
27
Issue
17
Pages
7653–7653
Publication date
26 August 2026
Language
EN