Accelerating the Adoption of Best Practice Research in Resuscitation Through Implementation Science: Identifying Gaps and Pathways

Translation of evidence-based resuscitation practices into clinical settings remains slow and inconsistent, a gap that significantly impacts survival and neurological outcomes. Implementation science offers a structured approach to accelerate adoption by identifying context-specific barriers-such as dispatcher workload, team choreography, and resource constraints-and tailoring strategies to overcome them. This paper applies the Knowledge-to-Action (KTA) framework to resuscitation, emphasizing stakeholder engagement, iterative monitoring, and sustainability. We provide detailed guidance across key resuscitation settings, including dispatch-assisted cardiopulmonary resuscitation (DA-CPR), in-hospital code teams, and emergency medical services (EMS). The manuscript introduces a comprehensive outcomes framework encompassing implementation, service/system, and patient-level metrics, and illustrates practical application through case examples such as DA-CPR and real-time feedback devices. To enhance scientific utility, we also present a decision-oriented table for pilot testing, offering healthcare institutions a roadmap for sustainable integration of evidence-based resuscitation protocols.