The Prognostic Significance of the Metabolic Score for Insulin Resistance and Subclinical Myocardial Injury for Cardiovascular Mortality in the General Population

Journal of Clinical Medicine 2026 Open access

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Authors: Patrick Cheon, Shannon O’Connor, Saeid Mirzai, Mohamed Ahmed Gamal Mostafa, Chuka Ononye, Elsayed Z. Soliman, Richard Kazibwe
DOI: 10.3390/jcm15031141
Cited by: 1
References: 31

Abstract

Background/Objectives: The Metabolic Score for Insulin Resistance (METS-IR), a non-insulin-based index of insulin resistance (IR), and subclinical myocardial injury (SCMI), identified by electrocardiogram (ECG), are each associated with cardiovascular disease (CVD). However, their joint impact on mortality remains unclear. We examined the association of the METS-IR with SCMI and evaluated the individual and combined associations of SCMI and IR with cardiovascular mortality. Methods: We analyzed adults without baseline CVD from the Third National Health and Nutrition Examination Survey (1988–1994) with mortality follow-up through 31 December 2019. The METS-IR was calculated from fasting glucose, triglycerides, high-density lipoprotein cholesterol, and body mass index and categorized as low (

Fields of Study & Subjects

Diabetes Cardiovascular Risks and Lipoproteins Adipokines Inflammation and Metabolic Diseases Cardiovascular Health and Risk Factors

Publication details

Journal / source
Journal of Clinical Medicine
Publisher
MDPI AG
Volume
15
Issue
3
Pages
1141–1141
Publication date
2 February 2026
Language
EN