Clinicopathological Characteristics and Survival Outcomes of Gastrointestinal Neuroendocrine Tumors in a Large Safety Net Hospital

Background/Objectives: Neuroendocrine tumors (NET) are heterogeneous, rare tumors predominantly of the gastrointestinal (GI) tract. Overall survival (OS) and prognostic factors of GI-NETs remain poorly understood. This study aimed to determine the clinicopathological characteristics and OS outcomes of GI-NETs in a demographically diverse population. Methods: All patients at a large tertiary safety-net hospital with a pathology-proven GI-NET diagnosis from 2001 through 2022 were identified. Demographic and tumor characteristics were collected from medical charts. For survival analysis, the Kaplan-Meier method and Cox regression analysis were used for group comparison. Results: A total of 222 cases were identified: 208 at six primary GI sites and 14 liver metastases only). Of these primary sites, rectum was the most frequent (27.4%). OS was the highest for appendiceal NETs (5-year OS: 95%) and lowest for stomach NETs (5-year OS 76%). Prognostic factors included age (5-year OS: 92% vs. 67% for