Pediatric Acute Poisoning: The Bipolar Evolution of the Poisoning Spectrum from 2019 to 2024 in Southwest China

Objective: To analyze the evolving epidemiological characteristics of pediatric poisoning from 2019 to 2024 in Southwest China, explore the changing patterns of pediatric poisoning in the post-pandemic era, and provide a reference for poisoning prevention and the development of effective prevention and treatment strategies. Methods: This study included 3923 cases of pediatric poisoning treated at the Emergency Department of West China Second University Hospital, Sichuan University. Clinical data such as gender, age, poisonous substance, and cause of poisoning were described. The chi-square trend test was used to analyze annual changes, and multivariate Poisson regression was employed to identify risk factors for hospitalization and for intentional poisoning in children. Results: The total number of cases increased significantly from 544 in 2019 to 1006 in 2024. A marked “polarization” pattern was observed: among children aged 1–3 years, unintentional ingestion of household chemicals predominated (n = 2332), whereas among adolescents aged 12–14 years, intentional self-poisoning cases surged by 580%, with the toxic agents shifting mainly to psychotropic prescription drugs. From 2019 to 2024, the proportions of intentional poisoning, psychotropic drug poisoning, psychiatric comorbidity, and delayed presentation all increased significantly. Poisson regression indicated that the post-pandemic period, psychiatric comorbidity, and exposure to psychotropic drugs were risk factors for intentional poisoning. Conclusions: Following the COVID-19 pandemic, mental health problems among adolescents have become increasingly prominent, and pediatric poisoning has exhibited a bipolarization pattern. Clinical prevention and control strategies should shift from simple emergency treatment to early intervention, psychological screening, and comprehensive prevention, so as to reduce health damage to children and the societal disease burden.