Nano-Enabled CRISPR-Cas Gene Editing for Cancer Therapeutics
Abstract
While CRISPR-Cas9 enables precise targeting of cancer-driving genetic aberrations, its clinical application is impeded by instability, delivery inefficiencies, and immunogenicity. Nanotechnology addresses these challenges by engineering nanocarriers that facilitate enhanced cellular uptake, promote efficient endosomal escape, and ensure targeted delivery. This review summarizes current progress in nano-integrated CRISPR-Cas systems for cancer therapeutics, highlighting recent advancements in stimuli-responsive nanoplatforms for precise genome editing and their prospects for clinical application.
Fields of Study & Subjects
CRISPR and Genetic Engineering
RNA Interference and Gene Delivery
Advanced biosensing and bioanalysis techniques
Publication details
- Journal / source
- Journal of Nanotheranostics
- Publisher
- MDPI AG
- Volume
- 7
- Issue
- 1
- Pages
- 6–6
- Publication date
- 9 March 2026
- Language
- EN