4-(4-Chlorophenyl)-6-phenyl-2-(prop-2-yn-1-yloxy)nicotinonitrile

Molbank 2026 Open access

Read full text
Authors: Diana Becerra, Diana Hurtado‐Rodríguez, Juan-Carlos Castillo
DOI: 10.3390/m2119
Cited by: 0
References: 20

Abstract

We report an efficient and transition-metal-free protocol for the propargylation of 4-(4-chlorophenyl)-2-oxo-6-phenyl-1,2-dihydropyridine-3-carbonitrile using propargyl bromide in the presence of cesium carbonate in dimethylsulfoxide under mild conditions. This synthetic transformation proceeds with marked chemoselectivity, furnishing the O-propargylated pyridine and the N-propargylated 2-pyridone in 75% and 8% yields, respectively. Both products were fully characterized by IR and NMR spectroscopy, as well as high-resolution mass spectrometry, confirming their molecular structures.

Fields of Study & Subjects

Catalytic Alkyne Reactions Catalytic Cross-Coupling Reactions Synthesis and Characterization of Pyrroles

Publication details

Journal / source
Molbank
Volume
2026
Issue
1
Pages
M2119–M2119
Publication date
4 January 2026
Language
EN