N-(3,6-Dimethoxy-2-nitrophenyl)acetamide

Molbank 2026 Open access

Read full text
Authors: Lina A. Al-Dulaimi, Joseph C. Bear, Jeremy K. Cockcroft, Giuseppe Trigiante, Fawaz Aldabbagh
DOI: 10.3390/m2147
Cited by: 0
References: 17

Abstract

1,4-Dimethoxy-2,3-dinitrobenzene (1) reduction using sodium hydrosulfite resulted in 3,6-dimethoxybenzene-1,2-diamine (2) and 3,6-dimethoxy-2-nitroaniline (3) in 24% and 59% yields, respectively. Nitroaniline 3 was acetylated with acetyl chloride to give N-(3,6-dimethoxy-2-nitrophenyl)acetamide (4) in a 65% yield and with acetic anhydride to give N-acetyl-N-(3,6-dimethoxy-2-nitrophenyl)acetamide (5) in 78% yield. Novel compounds 4 and 5 were characterized by FT-IR, 1H and 13C-NMR, and HRMS. The X-ray crystal structure of acetamide 4 is also presented.

Fields of Study & Subjects

Chemical Synthesis and Reactions Structural and Chemical Analysis of Organic and Inorganic Compounds Crystal structures of chemical compounds

Publication details

Journal / source
Molbank
Volume
2026
Issue
2
Pages
M2147–M2147
Publication date
10 March 2026
Language
EN