Anti-Neuroinflammatory Effects of a Representative Low-Molecular-Weight Component Isolated from Codium fragile Through Inhibition of the NF-κB Pathway in Microglia and Macrophage Cells
Abstract
The worldwide incidence of neurodegenerative diseases (ND), such as dementia, has increased, and neuroinflammation is considered a crucial factor in the development of ND. Codium fragile is considered ocean waste in many countries; however, some countries, including Korea, consume it as a food resource. In this study, a major low-molecular-weight component and chemical marker, uracil, was isolated from the aqueous extracts of C. fragile (AECF); additionally, its content was measured through HPLC quantitative analysis. AECF and uracil were examined for their anti-inflammatory activities against lipopolysaccharide (LPS)-stimulated BV2 microglia and RAW264.7 macrophage cell lines under inflammation conditions. The results showed that AECF and uracil inhibited the production of pro-inflammatory cytokines by suppressing the NF-κB pathway.
Fields of Study & Subjects
Genetics and Neurodevelopmental Disorders
Morinda citrifolia extract uses
Coenzyme Q10 studies and effects
Publication details
- Journal / source
- Marine Drugs
- Publisher
- MDPI AG
- Volume
- 24
- Issue
- 1
- Pages
- 38–38
- Publication date
- 13 January 2026
- Language
- EN