Corallomycetellains A–J, Cytotoxic Epipolythiodioxopiperazine Alkaloids Isolated from the Fungi Corallomycetella repens HDN23-0007

Marine Drugs 2026 Open access

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Authors: Chenqi Zhang, Luning Zhou, Shuo Zhao, Wenxue Wang, Xiaomin Zhang, qian che, T Zhu, Mei Han, D. D. Li
DOI: 10.3390/md24020062
Cited by: 2
References: 17

Abstract

Ten new epipolythiodioxopiperazine (ETP) alkaloids, named corallomycetellains A–J (1–10), along with one known analogue, haematocin (11), were isolated from the fungi Corallomycetella repens HDN23-0007. Their structures, including absolute configurations, were established by comprehensive spectroscopic data and electronic circular dichroism (ECD) calculations. Compounds 1–2 represent the first two examples of aranotin-type ETPs possessing an aromatic indole moiety. Compounds 2–4 all featured a unique C2-methyl disulfide substituent, whereas compound 4 additionally possessed a C2′-oxomethyl group. In in vitro cytotoxicity assays, compounds 7–10, which contained α–α′ polysulfide bridges, exhibited strong anticancer activity, with IC50 values ranging from 1.1 to 9.3 μM.

Fields of Study & Subjects

Microbial Natural Products and Biosynthesis Marine Sponges and Natural Products Seaweed-derived Bioactive Compounds

Publication details

Journal / source
Marine Drugs
Publisher
MDPI AG
Volume
24
Issue
2
Pages
62–62
Publication date
1 February 2026
Language
EN