Macroalgal Peptides with Predicted α-Glucosidase Inhibitory Activity: Preparation and Molecular Docking

Marine Drugs 2026 Open access

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Authors: Sakhi Ghelichi, Seyed Hossein Helalat, Mona Hajfathalian, Birte Svensson, Charlotte Jacobsen
DOI: 10.3390/md24030091
Cited by: 1
References: 59

Abstract

This study investigated the α-glucosidase inhibitory potential of enzymatic/alkaline treatments from Palmaria palmata using different proteases and pairwise combinations thereof. Treatments prepared with Alcalase®, Flavourzyme®, and Formea® Prime, alone or in combination, were evaluated for dose-dependent inhibitory activity. Alcalase®-derived treatments exhibited the highest α-glucosidase inhibition, achieving an IC50 of 2.48 mg·mL−1, outperforming other treatments and combinations. Membrane fractionation of the Alcalase®-derived treatment into >5 kDa, 3–5 kDa, 1–3 kDa, and

Fields of Study & Subjects

Protein Hydrolysis and Bioactive Peptides Enzyme Production and Characterization Seaweed-derived Bioactive Compounds

Publication details

Journal / source
Marine Drugs
Publisher
MDPI AG
Volume
24
Issue
3
Pages
91–91
Publication date
26 February 2026
Language
EN