Protective Effects of Chitosan and Rosuvastatin on Renal Structure and Lipid Metabolism in Rabbits Fed a High-Fat Diet

Medicina 2026 Open access

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Authors: Carlos Alberto Araujo Chagas, Lucas Alves Sarmento Pires, Beatriz Correa Rodriguez, Bruna Fernanda De Souza Ribeiro, Albino Fonseca, Márcio Antônio Babinski
DOI: 10.3390/medicina62010219
Cited by: 1
References: 32

Abstract

Background and Objectives: This study compared the effects of rosuvastatin and chitosan on the kidneys of rabbits fed a high-fat diet. Materials and Methods: In total, 28 New Zealand White rabbits (Oryctolagus cuniculus) were randomly divided into four groups of 7 rabbits: a control group (CG) fed a regular diet; a hyperlipidic group (HG) fed the regular diet and 20 mL of egg yolk daily; and the third (RG) and fourth (ChiG) groups fed the HG diet plus rosuvastatin and chitosan, respectively. Cholesterol, triglyceride, glucose, creatinine, and urea levels were analyzed. After kidney excision, glomerular height and length were analyzed and stereological analysis was conducted. The Kruskal–Wallis and Dunn multiple comparison tests were used for statistical analysis, and a p value of

Fields of Study & Subjects

Animal Nutrition and Physiology Lipoproteins and Cardiovascular Health Peroxisome Proliferator-Activated Receptors

Publication details

Journal / source
Medicina
Publisher
MDPI AG
Volume
62
Issue
1
Pages
219–219
Publication date
21 January 2026
Language
EN