Calcium Channel Blockers in Critical Care Medicine: Current Clinical Applications and Future Investigational Perspectives

Medical Sciences 2026 Open access

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Authors: Akram M Eraky, Yasser Mokhtar, Guy Grabau, Adnan Khan, Ashish Acharya, Nichole E. Gadd, Mark Jarosz, Abhishek Premkumar
DOI: 10.3390/medsci14020213
Cited by: 1
References: 76

Abstract

Calcium channel blockers (CCBs) are frequently used in the emergency department and intensive care unit for a wide range of critical conditions, including atrial fibrillation, hypertensive emergencies, acute pulmonary edema with sympathetic crashing, pulmonary hypertension, and vasospastic syndromes. However, their toxicity can lead to significant hemodynamic compromise, underscoring the importance of understanding their pharmacologic effects and safety profile. This review summarizes the current applications of CCBs in critically ill patients, evaluates their safety in congestive heart failure, and highlights emerging therapeutic roles and recent advances in the management of CCB toxicity.

Fields of Study & Subjects

Poisoning and overdose treatments Cardiac electrophysiology and arrhythmias Potassium and Related Disorders

Publication details

Journal / source
Medical Sciences
Publisher
MDPI AG
Volume
14
Issue
2
Pages
213–213
Publication date
25 April 2026
Language
EN