Cycloruthenated Imines: A Step into the Nanomolar Region

Molecules 2026 Open access

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Authors: Arsenii A. Vasil’ev, Ivan I. Troshin, Pavel G. Shangin, Ksenia M. Voroshilkina, Ilya A. Shutkov, Alexey A. Nazarov, Алексей В. Медведько
DOI: 10.3390/molecules31020315
Cited by: 0
References: 33

Abstract

A new series of promising and easily accessible antiproliferative agents based on cy-cloruthenated imines of benzene and thiophene carbaldehydes has been developed and fully characterized using UV-Vis spectroscopy, X-ray diffraction, NMR, HRMS, and cyclic voltammetry. The biological activity of these compounds was tested against A2780, cis-platin-resistant A2780, and HEK293 cell lines, and they exhibited nanomolar IC50 values. They also showed a selectivity index of up to 2.5, indicating their potential as promising antiproliferative compounds.

Fields of Study & Subjects

Metal complexes synthesis and properties Synthesis and biological activity Ferrocene Chemistry and Applications

Publication details

Journal / source
Molecules
Volume
31
Issue
2
Pages
315–315
Publication date
16 January 2026
Language
EN