A Novel Approach for the Synthesis of Peripherally Acting Dual Target Inhibitor of Cannabinoid-1 (CB1 Receptor) and Inducible Nitric Oxide Synthase (iNOS) (S-MRI-1867/Zevaquenabant)
Abstract
Zevaquenabant (S-MRI-1867) is a clinical-stage agent that is a peripherally restricted, potent antagonist of CB1R and an inhibitor of inducible nitric oxide synthase. A novel synthetic route to this highly selective active pharmaceutical agent is described in this paper. This route makes use of rationally installed chiral thio-substituted leaving group derived from a Bunte-salt reaction approach to yield diastereomeric compounds which are further processed to enantiopure compounds. The method will enable a rapid assembly of a variety of chiral sulfonyl amino compounds in this series.
Fields of Study & Subjects
Asymmetric Synthesis and Catalysis
Cannabis and Cannabinoid Research
Advanced Synthetic Organic Chemistry
Publication details
- Journal / source
- Molecules
- Volume
- 31
- Issue
- 3
- Pages
- 515–515
- Publication date
- 2 February 2026
- Language
- EN