X-Ray Diffraction of Collagen-Structured Water Molecules for Cancer Detection

Molecules 2026 Open access

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Authors: Sasha Murokh, Alexander Alekseev, Viacheslav Kubytskyi, Viacheslav Shcherbakov, Oleksii Avdieiev, Sergey A. Denisov, Ashkan Ajeer, Lois Adams, Charlene Greenwood, Keith D. Rogers, Lev G. Mourokh, Pavel Lazarev
DOI: 10.3390/molecules31040650
Cited by: 1
References: 35

Abstract

Structural biomarkers determined by X-ray scattering of the tissues can complement conventional histopathology and facilitate a fast triage procedure of cancer biopsy samples. It has been shown previously that lipid reflexes can distinguish cancerous from benign samples, except for fibroadenomas. In the present study, we demonstrate that fibroadenoma samples can be recognized using X-ray scattering of collagen. Moreover, we show that modifications in collagen structure are manifested in the water reflexes. Examination of diffraction patterns from water using two-dimensional Fourier transformation and machine learning yields excellent classification metrics in both synchrotron images and laboratory diffractometer data.

Fields of Study & Subjects

Advanced X-ray Imaging Techniques Collagen: Extraction and Characterization Enzyme Structure and Function

Publication details

Journal / source
Molecules
Publisher
MDPI AG
Volume
31
Issue
4
Pages
650–650
Publication date
13 February 2026
Language
EN