Potential Clinical Application of Determination of Bisphenols in Pericardial Fluid from Patients with Coronary Artery Disease

Bisphenols may negatively impact human health, including the heart and circulatory system. It is crucial to determine the presence of these xenobiotics in biological samples, including pericardial fluid. Pericardial fluid was collected from patients with acute coronary syndromes (ACS), and with coronary artery disease during coronary artery bypass surgery. Bisphenol residues were identified and quantified in samples from 15 patients. Quantitative analysis of bisphenols in the samples was performed by LC-MS/MS on a triple quadrupole (QqQ) mass spectrometer and electrospray ionization (ESI-/ESI+) was applied in the negative and positive ion modes, respectively. The procedure was successfully applied to the biomonitoring of free forms of 14 bisphenols in pericardial fluid. After statistical examination of the relationships between the selected variables, it was concluded that while male subjects demonstrated higher Body Mass Index (BMI), longer procedural times, and earlier troponin release, female subjects exhibited later but more pronounced increases in CK and TrI, suggesting differences in kinetics and physiological response.