Daphmacropomines A–E: Five Daphniphyllum Alkaloids from Daphniphyllum macropodum Miq.

Molecules 2026 Open access

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Authors: Lei Xu, Zhenpeng Niu, Yu Zhang, Hong Liang, Qian Zhao, Sheng Li, Duozhi Chen, Xiao Ding, Xiaojiang Hao
DOI: 10.3390/molecules31111943
Cited by: 1
References: 22

Abstract

Five new Daphniphyllum alkaloids, daphmacropomines A–E (1–5), were isolated from Daphniphyllum macropodum Miq. and structurally characterized. Compound 1 is an unprecedented Daphniphyllum alkaloid that features a unique 6/9/7/5/5 ring with a rare N-nitroso group. Compound 2 is the second Daphniphyllum alkaloid featuring a highly rearranged 6/6/6/7/5/6-fused skeleton. Compounds 3 and 4 are new yuzurimine-type alkaloids, and their structures were determined by extensive techniques including HRESIMS, NMR, ECD, and single-crystal X-ray. A plausible biosynthetic pathway for 1–4 is proposed. Furthermore, compounds 3 and 4 can induce lysosomal biogenesis and promote autophagic flux.

Fields of Study & Subjects

Advanced Synthetic Organic Chemistry Quinazolinone synthesis and applications Chemical synthesis and alkaloids

Publication details

Journal / source
Molecules
Publisher
MDPI AG
Volume
31
Issue
11
Pages
1943–1943
Publication date
3 June 2026
Language
EN