Prosthetic Management in Patients with Sjögren’s Syndrome: Challenges, Biomaterials and Pharmacological Considerations

Sjögren's syndrome (SS) is a chronic autoimmune disease characterized by severe hyposalivation and mucosal fragility, conditions that significantly complicate prosthetic rehabilitation.Reduced salivary flow compromises denture retention, increases mucosal trauma, and predisposes patients to infections such as oral candidiasis, limiting the success of conventional tissue-supported prostheses.This work summarizes current evidence on prosthetic management strategies in SS, highlighting the role of optimized biomaterials, digital manufacturing technologies, and implant-supported solutions.Emphasis is placed on multidisciplinary care, adjunctive pharmacological management of xerostomia, and long-term maintenance protocols to improve function, comfort, and quality of life in this complex patient population.