Effects of Aging in Combination with High-Fat or Ketogenic Diet on Skeletal Muscle Atrophy Following Denervation in C57BL/6J Mice

Nutrients 2026 Open access

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Authors: Mantas Dirmontas, Petras Minderis, Aivaras Ratkevičius
DOI: 10.3390/nu18030478
Cited by: 1
References: 34

Abstract

Objectives: The aim of this study was to investigate the effect of the interaction between aging and high-fat diet (HFD) or ketogenic diet (KD) on denervation-induced muscle atrophy. Methods: In this study, 6-, 19- and 27-month-old male mice were studied after 12 weeks’ exposure to a regular chow diet, RD (kcal distribution: 13% fat, 57% carbohydrate, 30% protein), HFD (kcal distribution: 60% fat, 20% carbohydrates, 20% protein), or KD (kcal distribution: 80% fat,

Fields of Study & Subjects

Muscle Physiology and Disorders Diet and metabolism studies Nutrition and Health in Aging

Publication details

Journal / source
Nutrients
Publisher
MDPI AG
Volume
18
Issue
3
Pages
478–478
Publication date
1 February 2026
Language
EN